How do you feel taking CBD oil? Be calm when starting out CBD oil, as you would do for any administered health products. However, CBD does not fall into this category since it contains little to no THC, or the psychoactive component in cannabis that causes a high. Given that both clobazam and CBD are metabolized by cytochrome P450 enzymes, a drug-drug interaction is not surprising.
A common misconception is that since CBD is made from CBD hemp as with marijuana, it will recreate the same psychoactive feeling” as associated with marijuana. A study published in 2016 by the company Ebbu reported they found eight different terpenes and three different cannabinoids that increase the potency of THC at the CB1 receptor.
And that must be the answer to this question about the CBD drug interactions. There’s some scientific evidence indicating that other hemp-derived cannabinoids and terpenes act synergistically to CBD. A CBD pain relief rub is the same thing as a CBD pain relief lotion or cream. If you suspect that you are not metabolizing CBD oil as expected, ask your doctor to test your cytochrome P450 enzyme system before adjusting your dosage.
The reason for the warning is that grapefruit contains compounds called furanocoumarins that bind with and effectively neutralize enzymes in the gut (specifically a type called CYP450 enzymes), which help break down and eliminate drugs from the body. Although CBD can decrease the activity of liver enzymes used to metabolize many prescription drugs it can also attenuate other drugs to make them more effective with smaller, less toxic doses.